PathScan®RP Phospho-p90RSK (Thr359) Sandwich ELISA Kit#91959,Cell Signaling Technology (CST),91959
The PathScan®RP Phospho-p90RSK (Thr359) Sandwich ELISA Kit #91959 detects endogenous levels of p90RSK protein phosphorylated at Thr359 in human cells. This kit sensitivity is shown in Figure 1. This kit detects proteins from the indicated species, as determined through in-house testing, but may also detect homologous proteins from other species.
Reactivity
Human, Rat, Monkey
Platform ID
BAB897559753
Cell Signaling Technology (CST)
Contact
Tel: 877-616-2355,978-867-2388
Fax: 877-616-2355
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Specifications
Scientific Background
The 90 kDa ribosomal S6 kinases (RSK1-4) are a family of widely expressed Ser/Thr kinases characterized by two nonidentical, functional kinase domains (1) and a carboxy-terminal docking site for extracellular signal-regulated kinases (ERKs) (2). Several sites both within and outside of the RSK kinase domain, including Ser380, Thr359, Ser363, and Thr573, are important for kinase activation (3). RSK1-3 are activated via coordinated phosphorylation by MAPKs, autophosphorylation, and phosphoinositide-3-OH kinase (PI3K) in response to many growth factors, polypeptide hormones, and neurotransmitters (3).Fisher, T.L. and Blenis, J. (1996)Mol Cell Biol16, 1212-9.Smith, J.A. et al. (1999)J Biol Chem274, 2893-8.Dalby, K.N. et al. (1998)J Biol Chem273, 1496-505.Alternate Names90 kDa ribosomal protein S6 kinase 1; dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1); HU-1; KS6A1; MAP kinase-activated protein kinase 1a; MAPK-activated protein kinase 1a; MAPKAP kinase 1a; MAPKAPK-1a; MAPKAPK1; MAPKAPK1A; p90-RSK 1; p90RSK; p90RSK1; p90S6K; ribosomal protein S6 kinase A1; ribosomal protein S6 kinase alpha 1; Ribosomal protein S6 kinase alpha-1; ribosomal protein S6 kinase, 90kDa, polypeptide 1; Ribosomal S6 kinase 1; RPS6KA1; RSK; RSK-1; RSK1; S6K-alpha 1; S6K-alpha-1
Synonyms
90 kDa ribosomal protein S6 kinase 1; dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1); HU-1; KS6A1; MAP kinase-activated protein kinase 1a; MAPK-activated protein kinase 1a; MAPKAP kinase 1a; MAPKAPK-1a; MAPKAPK1; MAPKAPK1A; p90-RSK 1; p90RSK; p90RSK1; p90S6K; ribosomal protein S6 kinase A1; ribosomal protein S6 kinase alpha 1; Ribosomal protein S6 kinase alpha-1; ribosomal protein S6 kinase, 90kDa, polypeptide 1; Ribosomal S6 kinase 1; RPS6KA1; RSK; RSK-1; RSK1; S6K-alpha 1; S6K-alpha-1
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