PathScan^®RP Tox/Tox2 Sandwich ELISA Kit#69258,Cell Signaling Technology (CST),69258

Thymocyte selection-associated high mobility group box protein (Tox) is a DNA-binding nuclear factor and member of the evolutionarily conserved high-motility group (HMG)-box superfamily. Tox also defines a small subfamily of proteins that include Tox2, Tox3, and Tox4, all of which are highly conserved in vertebrate species but have unique tissue expression patterns and functions (1,2).Tox plays a key role in T cell development in the thymus during positive selection (3-5). A study in Tox-deficient mice also revealed a requirement for Tox in CD4 T cell and NK cell lineage development, including NKT cells, FoxP3+T regulatory T cells, and lymphoid tissue-inducer (LTi) cells (6-8). Although Tox expression is primarily restricted to developing immune cells in normal tissues, Tox is induced by high antigen stimulation during chronic viral infection or cancer, regulating T cell persistence and exhaustion (9-12). Tox has also been shown to be aberrantly expressed in cutaneous T cell lymphomas (13-14).O'Flaherty, E. and Kaye, J. (2003)BMC Genomics4, 13.Aliahmad, P. et al. (2012)Curr Opin Immunol24, 173-7.Wilkinson, B. et al. (2002)Nat Immunol3, 272-80.Aliahmad, P. et al. (2004)J Exp Med199, 1089-99.Chi, T.H. et al. (2002)Nature418, 195-9.Aliahmad, P. and Kaye, J. (2008)J Exp Med205, 245-56.Aliahmad, P. et al. (2010)Nat Immunol11, 945-52.Yun, S. et al. (2011)Immunol Lett136, 29-36.Page, N. et al. (2018)Immunity48, 937-950.e8.Alfei, F. et al. (2019)Nature571, 265-9.Yao, C. et al. (2019)Nat Immunol20, 890-901.Wang, X. et al. (2019)J Hepatolpii: S0168-8278(19)30301-0. doi: 10.1016/j.jhep.2019.05.015.Morimura, S. et al. (2014)Arch Dermatol Res306, 843-9.Huang, Y. et al. (2014)Oncotarget5, 4418-25.Alternate NamesC20orf100; dJ1108D11.2; dJ495O3.1; GCX-1; GCX1; granulosa cell HMG box 1; Granulosa cell HMG box protein 1; granulosa cell HMG-box protein 1; KIAA0808; MGC15880; thymocyte selection associated high mobility group box; thymocyte selection-associated high mobility group box; Thymocyte selection-associated high mobility group box protein TOX; Thymus high mobility group box protein TOX; TOX; TOX high mobility group box family member 2; TOX1; TOX2

C20orf100; dJ1108D11.2; dJ495O3.1; GCX-1; GCX1; granulosa cell HMG box 1; Granulosa cell HMG box protein 1; granulosa cell HMG-box protein 1; KIAA0808; MGC15880; thymocyte selection associated high mobility group box; thymocyte selection-associated high mobility group box; Thymocyte selection-associated high mobility group box protein TOX; Thymus high mobility group box protein TOX; TOX; TOX high mobility group box family member 2; TOX1; TOX2