Peptidyl-Prolyl Cis-Trans Isomerase NIMA-Interacting 1 (PIN1) Antibody,Abbexa,abx034932
Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.
Host
Mouse
Reactivity
Human, Mouse, Rat, Monkey
Application
ELISA, WB, IHC
Conjugate
Unconjugated
Platform ID
BAB332353711
Abbexa
Contact
Tel: +44 (0) 1223 755950
Fax: +44 (0) 1223 755951
Email:
Product Specifications
Specifications
NamePeptidyl-Prolyl Cis-Trans Isomerase NIMA-Interacting 1 (PIN1) Antibody
Cat. No.abx034932
Accession NumberQ13526
HostMouse
IsotypeIgG1
ReactivityHuman, Mouse, Rat, Monkey
ConjugationUnconjugated
ApplicationELISA, WB, IHC
Working DilutionsWB: 1/1000, IHC-P: 1/25. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
ClonalityMonoclonal
Molecular WeightCalculated MW: 18.2 kDa
ImmunogenPurified His-tagged Human PIN1 protein
PurityPurified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Appearance/FormLiquid
FormulationPBS containing 0.09% sodium azide.
StorageAliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Regulatory StatusResearch Use Only
Category Paths
- Products>Primary Antibodies>IHC Antibodies
- Products>Primary Antibodies>Monoclonal Antibodies
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