PerCP/Cyanine5.5 anti-human CD144 VE-Cadherin Antibody anti-CD144 - BV9,BioLegend,348509

Clone BV9 has been shown to block VE-cadherin, causing a redistribution of VE-cadherin away from intracellular junctions.6This clone binds to EC3-EC4 region in the extracellular domain of human VE-cadherin.7Additional reported applications (for the relevant formats) include: Western Blotting1,2, immunofluorescence microscopy1,3, immunoprecipitation1,4, blocking angiogenesisin vitro4,5, inhibiting VE-cadherin reorganization4, and inducing endothelial cell apoptosis4.

Host

Mouse

Reactivity

Human

Application

FC - Quality tested

Platform ID

BAB774741263

BioLegend

Headquarters

8999 BioLegend Way San Diego, CA 92121 United States

BioLegend

Contact

Tel: 1-858-455-9588
Fax: +49 (4131) 7023913

Email:

Product Specifications
Scientific Background

Specifications

NamePerCP/Cyanine5.5 anti-human CD144 VE-Cadherin Antibody anti-CD144 - BV9
Cat. No.348509
HostMouse
RRIDAB_2562927 (BioLegend Cat. No. 348509)AB_2562928 (BioLegend Cat. No. 348510)
IsotypeMouse IgG2a, κ
ReactivityHuman
ApplicationFC - Quality tested
ClonalityMonoclonal
Clone NumberBV9
ConcentrationLot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.)
TargetCD144
PurityThe antibody was purified by affinity chromatography and conjugated with PerCP/Cyanine5.5 under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

CD144, also known as VE-cadherin and cadherin-5, is a 140 kD glycoprotein which is composed of five extracellular cadherin repeats and a highly conserved cytoplasmic tail region. It is a calcium-dependent transmembrane cell-cell adhesion molecule localized at the intercellular boundaries of endothelial cells, hematopoietic stem cells, and perineurial cells. It functions as a classic cadherin by mediating homophilic adhesion and functions as a plasma membrane attachment site for the cytoskeleton. CD144 is thought to play a role in vascular development, permeability, and remodeling.

Category Paths

Request a product

Please provide the required information below so that we can quickly source your products.