PerCP/Cyanine5.5 anti-human CD45RA Antibody anti-CD45RA - HI100,BioLegend,304122

Additional reported applications (for relevant formats of this clone) include: inhibition of CD45 functions2, immunohistochemical staining of frozen tissue sections3and formalin-fixed paraffin-embedded tissue sections4, and immunocytochemistry15,16.

Host

Mouse

Reactivity

Human

Application

FC - Quality testedSB - Community Verified

Platform ID

BAB230201388

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Tel: 1-858-455-9588
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Product Specifications
Scientific Background

Specifications

NamePerCP/Cyanine5.5 anti-human CD45RA Antibody anti-CD45RA - HI100
Cat. No.304122
HostMouse
RRIDAB_893358 (BioLegend Cat. No. 304121)AB_893357 (BioLegend Cat. No. 304122)
IsotypeMouse IgG2b, κ
ReactivityHuman
ApplicationFC - Quality testedSB - Community Verified
ClonalityMonoclonal
Clone NumberHI100
ConcentrationLot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.)
TargetCD45RA
PurityThe antibody was purified by affinity chromatography, and conjugated with PerCP/Cyanine5.5 under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
StorageThe CD45RA antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

CD45RA is a 205-220 kD single chain type I glycoprotein. It is an exon 4 splice variant of the tyrosine phosphatase CD45. The CD45RA isoform is expressed on resting/naïve T cells, medullary thymocytes, B cells and monocytes. CD45RA enhances both T cell receptor and B cell receptor signaling. CD45 non-covalently associates with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4. CD45 has also been reported to bind galectin-1. CD45 isoform expression can change in response to cytokines.

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