PerCP/Cyanine5.5 anti-human/mouse Bcl-6 Antibody anti-Bcl-6 - 7D1,BioLegend,358508
Additional reported applications (for the relevant formats) include: Western blotting1,2,3.NOTE: For flow cytometric staining with this clone, True-Nuclear™ Transcription Factor Buffer Set (Cat. No.424401) offers improved staining and is highly recommended.
Host
Rat
Reactivity
Human, Mouse
Application
ICFC -Quality tested
Platform ID
BAB321779938
BioLegend
Contact
Tel: 1-858-455-9588
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Product Specifications
Scientific Background
Specifications
NamePerCP/Cyanine5.5 anti-human/mouse Bcl-6 Antibody anti-Bcl-6 - 7D1
Cat. No.358508
HostRat
RRIDAB_2566191 (BioLegend Cat. No. 358507)AB_2566192 (BioLegend Cat. No. 358508)
IsotypeRat IgG2a, κ
ReactivityHuman, Mouse
ApplicationICFC -Quality tested
ClonalityMonoclonal
Clone Number7D1
ConcentrationLot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.)
TargetBcl-6
ImmunogenSequence 226-398 of murine BCL6 fused with GST
PurityThe antibody was purified by affinity chromatography and conjugated with PerCP/Cyanine5.5 under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only
Scientific Background
B-cell lymphoma 6 (Bcl-6), is an 80 kD homodimer, member of the BTB-POZ zinc finger family. It contains 1 BTB (POZ) domain and 6 C2H2-type zinc fingers. Bcl-6 is a transcriptional repressor, master regulator of germinal center reaction. On B cells, Bcl-6 induces proliferation, antibody class switch and affinity maturation, while inhibits its differentiation to plasma cells. On T cells, Bcl-6 induces its differentiation to TFH. This molecule is also expressed in some B cell lymphomas and breast cancer cells.
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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