PerCP/Cyanine5.5 anti-mouse CD11a Antibody anti-CD11a - M17/4,BioLegend,101123
The M17/4 antibody can block CD11a-mediated cellular adhesion. Additional reported applications of this antibody (for the relevant formats) include: immunoprecipitation1,2,in vitroblocking of cell-cell adhesion1,2and FOXP3 expression5, and immunohistochemical staining of acetone-fixed frozen sections3. The M17/4 antibody does not block the binding of 2D7 antibody (Cat. No. 101002) to CD11a. The LEAF™ purified antibody (Endotoxin <0.1 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 101110). Forin vivostudies or highly sensitive assays, we recommend Ultra-LEAF™ purified antibody (Cat. No. 101118) with a lower endotoxin limit than standard LEAF™ purified antibodies (Endotoxin <0.01 EU/µg).
Host
Rat
Reactivity
Mouse
Application
FC - Quality tested
Platform ID
BAB435536573
BioLegend
Contact
Tel: 1-858-455-9588
Fax: +49 (4131) 7023913
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Product Specifications
Scientific Background
Specifications
NamePerCP/Cyanine5.5 anti-mouse CD11a Antibody anti-CD11a - M17/4
Cat. No.101123
HostRat
RRIDAB_2562931 (BioLegend Cat. No. 101123)AB_2562932 (BioLegend Cat. No. 101124)
IsotypeRat IgG2a, κ
ReactivityMouse
ApplicationFC - Quality tested
ClonalityMonoclonal
Clone NumberM17/4
Concentration0.2 mg/ml
TargetCD11a
ImmunogenC57BL/6 mouse splenic secondary cytotoxic T cells
PurityThe antibody was purified by affinity chromatography and conjugated with PerCP/Cyanine5.5 under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only
Scientific Background
CD11a is a 180 kD glycoprotein, also known as αLintegrin, LFA-1 α, Ly-15, or Ly-21. It is a member of the integrin family, primarily expressed on lymphocytes, monocytes/macrophages, and granulocytes. In association with CD18, the CD11a/CD18 complex forms LFA-1. CD11a plays an important role in intercellular adhesion and costimulation by binding its ligands, ICAM-1 (CD54), ICAM-2 (CD102), and ICAM-3 (CD50).
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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