PerCP/Fire™ 780 anti-human CD8b Antibody, CD8b, S21011A,BioLegend,387317
Clone S21011A does not interfere with the binding of CD8α binding antibodies (SK1, HIT8a, RPA-T8).Clone S21011A shows comparable staining signals on 4% paraformaldehyde-fixed cells and unfixed cells.Based on in-house testing, clone S21011A clone reacts with an epitope that is exclusively present on human CD8b, whereas clone QA20A40 reacts with an epitope formed by a heterodimer of human CD8a and CD8b chains.
Reactivity
Human
Application
FC - Quality tested
Platform ID
BAB761525081
BioLegend
Contact
Tel: 1-858-455-9588
Fax: +49 (4131) 7023913
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Product Specifications
Scientific Background
Specifications
NamePerCP/Fire™ 780 anti-human CD8b Antibody, CD8b, S21011A
Cat. No.387317
RRIDAB_3699040 (BioLegend Cat. No. 387317)AB_3699040 (BioLegend Cat. No. 387318)
IsotypeMouse IgG1, κ
ReactivityHuman
ApplicationFC - Quality tested
ClonalityMonoclonal
Clone NumberS21011A
ConcentrationLot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.)
TargetCD8beta
ImmunogenHuman CD8α/CD8β-transfected cells
PurityThe antibody was purified by affinity chromatography and conjugated with PerCP/Fire™ 780 under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only
Scientific Background
CD8b or CD8β antigen is also known as Lyt3, or Ly-3. It is a member of the immunoglobulin superfamily expressed on most thymocytes, and some mature T cell subsets. CD8β forms heterodimers with the CD8α chain (CD8a). CD8 is an antigen co-receptor on T cells that interacts with MHC class I on antigen-presenting cells. CD8 participates in T cell activation through its association with the T cell receptor complex and protein tyrosine kinase LCK (p56lck).
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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