PerCP/Fire™ 806 anti-human CD28 Antibody, CD28, S20013B,BioLegend,377815
Clone S20013B antibody can completely block the binding of clone CD28.2 on target.Clone S20013B can partially block Clone S20013F on target.Clone S20013B can increase anti-CD3 induced human peripheral T-cell proliferation.Clone S20013B is a superagonistic antibody raised towards human CD28, and can induce activation, proliferation of human peripheral T cells without anti-CD3 stimulation.
Host
Mouse
Reactivity
Human
Application
FC - Quality tested
Platform ID
BAB447819410
BioLegend
Contact
Tel: 1-858-455-9588
Fax: +49 (4131) 7023913
Email:
Specifications
Scientific Background
CD28 is a 44 kD disulfide-linked homodimeric type I glycoprotein. It is a member of the immunoglobulin superfamily and is also known as T44 or Tp44. CD28 is expressed on most T lineage cells, NK cell subsets, and plasma cells. CD28 binds both CD80 and CD86 using a highly conserved motif MYPPY in the CDR3-like loop. CD28 is considered a major co-stimulatory molecule, inducing T lymphocyte activation and IL-2 synthesis, and preventing cell death.In vitrostudies indicate that ligation of CD28 on T cells by CD80 and CD86 on antigen presenting cells provides a costimulatory signal required for T cell activation and proliferation.
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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