Phospho-AMPKα (Thr172) Antibody, Rabbit MAb,Sino Biological,110537-R0007

Monoclonal Rabbit IgG Clone #0007

Host

Rabbit

Reactivity

Human Predicted to React with: Species predicted to react based on 100% sequence homology: Mouse, Cynomolgus, Pig

Application

WB

Conjugate

Unconjugated

Platform ID

BAB488097308

Sino Biological

Headquarters

Building 9, Yard 18, Kechuang 10th Street, Beijing Economic-Technological Development Area, Daxing District, Beijing 100176, China

Sino Biological

Contact

Tel: 400-890-9989
Fax:

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NamePhospho-AMPKα (Thr172) Antibody, Rabbit MAb
Cat. No.110537-R0007
HostRabbit
RRIDAB_3677072
ReactivityHuman Predicted to React with: Species predicted to react based on 100% sequence homology: Mouse, Cynomolgus, Pig
ConjugationUnconjugated
ApplicationWB
Working DilutionsWB:1:2000-1:20000
ImmunogenA synthetic peptide corresponding to the residues around (Thr172) of Human Phospho-AMPKα
PurityProtein A
Appearance/FormLiquid
ShippingThis antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Formulation10 mM sodium HEPES, 150 mM NaCl, 100 μg/mL BSA, 50% glycerol, pH 7.5
StorageThis antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Scientific Background

The PRKAA1 gene encodes the catalytic alpha-subunit of 5' AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor that maintains energy homeostasis within the cell and is activated when the AMP/ATP ratio increases. Moreover, AMPK has been shown to be involved in inhibiting tumour growth and metastasis, and has also been implicated in the pathology of neurodegenerative and cardiac disorders. All 5 tested tag SNPs of the PRKAA1 gene (rs13361707, rs154268, rs3805486, rs6882903, and rs10074991) were significantly associated with gastric cancer.An inhibitor of PRKAA1 promoted the secretion of IL6, whereas an agonist of PRKAA1 suppressed the production of IL6.

Synonyms

Anti-AMPK Antibody; Anti-AMPK alpha 1 Antibody; Anti-AMPK1 Antibody; Anti-AMPKa1 Antibody; protein kinase, AMP-activated, alpha 1 catalytic subunit

Category Paths

Request a product

Please provide the required information below so that we can quickly source your products.