Phospho-CREB (Ser133) Antibody, Rabbit MAb,Sino Biological,110398-R0256

Monoclonal Rabbit IgG Clone #0256

Host

Rabbit

Reactivity

Human

Application

IHC-P

Conjugate

Unconjugated

Platform ID

BAB425716001

Sino Biological

Headquarters

Building 9, Yard 18, Kechuang 10th Street, Beijing Economic-Technological Development Area, Daxing District, Beijing 100176, China

Sino Biological

Contact

Tel: 400-890-9989
Fax:

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NamePhospho-CREB (Ser133) Antibody, Rabbit MAb
Cat. No.110398-R0256
HostRabbit
ReactivityHuman
ConjugationUnconjugated
ApplicationIHC-P
Working DilutionsIHC-P:1:100-1:500
ImmunogenA synthetic peptide corresponding to residues around Ser133 of Human Phospho-CREB
PurityProtein A
Appearance/FormLiquid
ShippingThis antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Formulation10 mM sodium HEPES, 150 mM NaCl, 100 μg/mL BSA, 50% glycerol, pH 7.5
StorageThis antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Scientific Background

CAMP responsive element binding protein 1, also known as CREB-1, plays multiple functions as a transcription factor in gene regulation. This protein is a CREB transcription factor that is a member of the leucine zipper family of DNA-binding proteins. CREB1 proteins are also known to be expressed in several spliced isoforms that act as transcriptional activators or repressors. The activator isoforms, possessing the functional domains for kinase induction and for interaction with other transcriptional regulators, act as transcriptional activators.The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. CREB-1 has a complex influence on behavioural responses to drugs of abuse which varies depending on the brain region in which it is expressed. CREB-1 is important for serotonin (5-HT)-induced long-term facilitation (LTF) of the sensorimotor synapse in Aplysia.

Synonyms

Anti-CREB Antibody; Anti-CREB-1 Antibody; cAMP responsive element binding protein 1

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