Phospho-CaMKII (Thr286) Antibody, Rabbit MAb,Sino Biological,111903-R0006

Monoclonal Rabbit IgG Clone #0006

Host

Rabbit

Reactivity

Human

Application

WB

Conjugate

Unconjugated

Platform ID

BAB363134790

Sino Biological

Headquarters

Building 9, Yard 18, Kechuang 10th Street, Beijing Economic-Technological Development Area, Daxing District, Beijing 100176, China

Sino Biological

Contact

Tel: 400-890-9989
Fax:

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NamePhospho-CaMKII (Thr286) Antibody, Rabbit MAb
Cat. No.111903-R0006
HostRabbit
ReactivityHuman
ConjugationUnconjugated
ApplicationWB
Working DilutionsWB:1:1000-1:10000
ImmunogenA synthetic peptide corresponding to residues around Thr286 of Human Phospho-CaMKII
PurityProtein A
Appearance/FormLiquid
ShippingThis antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Formulation10 mM sodium HEPES, 150 mM NaCl, 100 μg/mL BSA, 50% glycerol, pH 7.5
StorageThis antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Scientific Background

Ca 2+ /calmodulin-dependent protein kinase2A (CAMK2A) belongs to the serine/threonine protein kinase family and, together with other 28 different isoforms, belongs to the Ca 2+ / calmodulin-dependent protein kinase subfamily. CaM kinase Ⅱ is thought to be an important mediator of learning and memory and is also necessary for Ca 2+ homeostasis and reuptake in cardiomyocytes chloride transport in epithelia, positive T-cell selection, and CD8 T-cell activation. CAMKIIA is one of the major forms of CAMKII. It has been found to play a critical role in sustaining activation of CAMKII at the postsynaptic density. Studies have found that knockout mice without CAMKIIA demonstrate a low frequency of LTP. Additionally, these mice do not form persistent, stable place cells in the hippocampus.

Synonyms

Anti-CAMKA Antibody; Anti-CaMKIIalpha Antibody; Anti-CaMKIINalpha Antibody; Anti-CaMKIIα Antibody; Anti-KIAA0968 Antibody; Anti-MRD53 Antibody; Anti-MRT63 Antibody; calcium/calmodulin-dependent protein kinase II alpha

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