Phospho-EGF Receptor (Thr669, Thr693) Antibody, Rabbit MAb,Sino Biological,111676-R0016

Monoclonal Rabbit IgG Clone #0016

Host

Rabbit

Reactivity

Human Predicted to React with: Species predicted to react based on 100% sequence homology: Mouse, Cynomolgus

Application

WB

Conjugate

Unconjugated

Platform ID

BAB613259730

Sino Biological

Headquarters

Building 9, Yard 18, Kechuang 10th Street, Beijing Economic-Technological Development Area, Daxing District, Beijing 100176, China

Sino Biological

Contact

Tel: 400-890-9989
Fax:

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NamePhospho-EGF Receptor (Thr669, Thr693) Antibody, Rabbit MAb
Cat. No.111676-R0016
HostRabbit
RRIDAB_3677086
ReactivityHuman Predicted to React with: Species predicted to react based on 100% sequence homology: Mouse, Cynomolgus
ConjugationUnconjugated
ApplicationWB
Working DilutionsWB:1:2000-1:20000
ImmunogenA synthetic peptide corresponding to the residues around (Thr669) of Human EGF Receptor
PurityProtein A
Appearance/FormLiquid
ShippingThis antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Formulation10 mM sodium HEPES, 150 mM NaCl, 100 μg/mL BSA, 50% glycerol, pH 7.5
StorageThis antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Scientific Background

As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently. Cancer Immunotherapy Immune Checkpoint Immunotherapy Targeted Therapy

Synonyms

Anti-ERBB Antibody; Anti-ERBB1 Antibody; Anti-ERRP Antibody; Anti-HER1 Antibody; Anti-mENA Antibody; Anti-NISBD2 Antibody; Anti-PIG61 Antibody; epidermal growth factor receptor

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