Phospho-IRF-3 (Ser386) (E7J8G) Rabbit Monoclonal Antibody (Alexa Fluor®647 Conjugate)#96421,Cell Signaling Technology (CST),96421

Phospho-IRF-3 (Ser386) (E7J8G) Rabbit Monoclonal Antibody (Alexa Fluor®647 Conjugate) recognizes endogenous levels of IRF-3 protein only when phosphorylated at Ser386.

Host

Rabbit

Reactivity

Human

Application

Flow Cytometry (Fixed/Permeabilized): 1:50

Platform ID

BAB702819480

Cell Signaling Technology (CST)

Headquarters

3 Trask Lane Danvers, MA 01923

Cell Signaling Technology (CST)

Contact

Tel: 877-616-2355,978-867-2388
Fax: 877-616-2355

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NamePhospho-IRF-3 (Ser386) (E7J8G) Rabbit Monoclonal Antibody (Alexa Fluor®647 Conjugate)#96421
Cat. No.96421
Accession NumberQ14653
Gene ID (Entrez)14653, 3661
HostRabbit
SensitivityEndogenous
ReactivityHuman
ApplicationFlow Cytometry (Fixed/Permeabilized): 1:50
ImmunogenIgG
FormulationSupplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg/ml BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze.
StorageSupplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg/ml BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

Interferon regulatory factors (IRFs) comprise a family of transcription factors that function within the Jak/Stat pathway to regulate interferon (IFN) and IFN-inducible gene expression in response to viral infection (1). IRFs play an important role in pathogen defense, autoimmunity, lymphocyte development, cell growth, and susceptibility to transformation. The IRF family includes nine members: IRF-1, IRF-2, IRF-9/ISGF3γ, IRF-3, IRF-4 (Pip/LSIRF/ICSAT), IRF-5, IRF-6, IRF-7, and IRF-8/ICSBP. All IRF proteins share homology in their amino-terminal DNA-binding domains. IRF family members regulate transcription through interactions with proteins that share similar DNA-binding motifs, such as IFN-stimulated response elements (ISRE), IFN consensus sequences (ICS), and IFN regulatory elements (IRF-E) (2).Taniguchi, T. et al. (2001)Annu Rev Immunol19, 623-55.Honda, K. and Taniguchi, T. (2006)Nat Rev Immunol6, 644-58.Alternate NamesIIAE7; Interferon regulatory factor 3; IRF-3; IRF3

Synonyms

IIAE7; Interferon regulatory factor 3; IRF-3; IRF3

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