Phospho-IkappaB alpha (Ser32) (14D4) Rabbit Monoclonal Antibody (BSA and Azide Free)#71278,Cell Signaling Technology (CST),71278

The NF-κB/Rel transcription factors are present in the cytosol in an inactive state complexed with the inhibitory IκB proteins (1-3). Activation occurs via phosphorylation of IκBα at Ser32 and Ser36 followed by proteasome-mediated degradation that results in the release and nuclear translocation of active NF-κB (3-7). IκBα phosphorylation and resulting Rel-dependent transcription are activated by a highly diverse group of extracellular signals including inflammatory cytokines, growth factors, and chemokines. Kinases that phosphorylate IκB at these activating sites have been identified (8).Baeuerle, P.A. and Baltimore, D. (1988)Science242, 540-6.Beg, A.A. and Baldwin, A.S. (1993)Genes Dev7, 2064-70.Finco, T.S. et al. (1994)Proc Natl Acad Sci USA91, 11884-8.Brown, K. et al. (1995)Science267, 1485-8.Brockman, J.A. et al. (1995)Mol Cell Biol15, 2809-18.Traenckner, E.B. et al. (1995)EMBO J14, 2876-83.Chen, Z.J. et al. (1996)Cell84, 853-62.Karin, M. and Ben-Neriah, Y. (2000)Annu Rev Immunol18, 621-63.Alternate NamesEDAID2; I-kappa-B-alpha; IkappaBalpha; IkB-alpha; IKBA; MAD-3; MAD3; Major histocompatibility complex enhancer-binding protein MAD3; NF-kappa-B inhibitor alpha; NFKB inhibitor alpha; NFKBI; NFKBIA; nuclear factor of kappa light chain gene enhancer in B-cells; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha

EDAID2; I-kappa-B-alpha; IkappaBalpha; IkB-alpha; IKBA; MAD-3; MAD3; Major histocompatibility complex enhancer-binding protein MAD3; NF-kappa-B inhibitor alpha; NFKB inhibitor alpha; NFKBI; NFKBIA; nuclear factor of kappa light chain gene enhancer in B-cells; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha