Phospho-Jak2 (Tyr1007) (D15E2) Rabbit Monoclonal Antibody#4406,Cell Signaling Technology (CST),4406

Phospho-Jak2 (Tyr1007) (D15E2) Rabbit Monoclonal Antibody detects endogenous levels of Jak2 when phosphorylated at Tyr1007. This antibody can also detect double phosphorylation at Tyr1007 and Tyr1008. Cross-reactivity may be observed with phosphorylated Jak3 and Tyk2.

Host

Rabbit

Reactivity

Human, Mouse

Application

Western Blotting: 1:1000

Platform ID

BAB560254151

Cell Signaling Technology (CST)

Headquarters

3 Trask Lane Danvers, MA 01923

Cell Signaling Technology (CST)

Contact

Tel: 877-616-2355,978-867-2388
Fax: 877-616-2355

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NamePhospho-Jak2 (Tyr1007) (D15E2) Rabbit Monoclonal Antibody#4406
Cat. No.4406
Accession NumberO60674
Gene ID (Entrez)60674, 3717
HostRabbit
SensitivityEndogenous
ReactivityHuman, Mouse
ApplicationWestern Blotting: 1:1000
Molecular Weight125
ImmunogenIgG
FormulationSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
StorageSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Regulatory StatusResearch Use Only

Scientific Background

Members of the Janus family of tyrosine kinases (Jak1, Jak2, Jak3, and Tyk2) are activated by ligands binding to a number of associated cytokine receptors (1). Upon cytokine receptor activation, Jak proteins become autophosphorylated and phosphorylate their associated receptors to provide multiple binding sites for signaling proteins. These associated signaling proteins, such as Stats (2), Shc (3), insulin receptor substrates (4), and focal adhesion kinase (FAK) (5), typically contain SH2 or other phospho-tyrosine-binding domains.Leonard, W.J. and O'Shea, J.J. (1998)Annu Rev Immunol16, 293-322.Darnell, J.E. (1997)Science277, 1630-5.VanderKuur, J. et al. (1995)J Biol Chem270, 7587-93.Argetsinger, L.S. et al. (1995)J Biol Chem270, 14685-92.Zhu, T. et al. (1998)J Biol Chem273, 10682-9.Alternate NamesJAK-2; JAK2; Janus kinase 2; Janus kinase 2 (a protein tyrosine kinase); JTK10; Tyrosine-protein kinase JAK2

Synonyms

JAK-2; JAK2; Janus kinase 2; Janus kinase 2 (a protein tyrosine kinase); JTK10; Tyrosine-protein kinase JAK2

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