Phospho-NPM1 (Thr199) (E4C7S) Rabbit Monoclonal Antibody (BSA and Azide Free)#52911,Cell Signaling Technology (CST),52911

Phospho-NPM1 (Thr199) (E4C7S) Rabbit Monoclonal Antibody (BSA and Azide Free) recognizes endogenous levels of NPM1 protein only when phosphorylated at Thr199.

Host

Rabbit

Reactivity

Human, Mouse, Rat

Platform ID

BAB623634978

Cell Signaling Technology (CST)

Headquarters

3 Trask Lane Danvers, MA 01923

Cell Signaling Technology (CST)

Contact

Tel: 877-616-2355,978-867-2388
Fax: 877-616-2355

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NamePhospho-NPM1 (Thr199) (E4C7S) Rabbit Monoclonal Antibody (BSA and Azide Free)#52911
Cat. No.52911
Accession NumberP06748
Gene ID (Entrez)06748, 4869
HostRabbit
SensitivityEndogenous
ReactivityHuman, Mouse, Rat
Molecular Weight38
ImmunogenIgG
FormulationThis product is the carrier free version of product #75984. All data were generated using the same antibody clone in the standard formulation which contains BSA and glycerol.This formulation is ideal for use with technologies requiring specialized or custom antibody labeling, including fluorophores, metals, lanthanides, and oligonucleotides. It is not recommended for ChIP, ChIP-seq, CUT&RUN or CUT&Tag assays. If you require a carrier free formulation for chromatin profiling, pleasecontact us. Optimal dilutions/concentrations should be determined by the end user.BSA and Azide Free antibodies are quality control tested by size exclusion chromatography (SEC) to determine antibody integrity.
StorageStore at -20°C.This product will freeze at -20°C so it is recommended to aliquot into single-use vials to avoid multiple freeze/thaw cycles.A slight precipitate may be present and can be dissolved by gently vortexing. This will not interfere with antibody performance.
Regulatory StatusResearch Use Only

Scientific Background

Nucleophosmin (NPM1), also known as B23, numatrin, or NO38, is an abundant phosphoprotein primarily found in nucleoli. It has been implicated in several distinct cellular functions, including assembly and transport of ribosomes, cytoplasmic/nuclear trafficking, regulation of DNA polymerase α activity, centrosome duplication, and molecular chaperoning activities (1,2). TheNPM1gene is also known for its fusion with the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase. The NPM1 portion contributes to transformation by providing a dimerization domain, which activates the fused kinase (3,4).Okuda, M. et al. (2000)Cell103, 127-140.Takemura, M. et al. (1999)J. Biochem. (Tokyo)125, 904-909.Morris, S.W. et al. (1994)Science263, 1281-1284.Bischof, D. et al. (1997)Mol. Cell. Biol.17, 2312-2325.Alternate NamesB23; MGC104254; NPM; NPM1; Nucleolar phosphoprotein B23; Nucleolar protein NO38; Nucleophosmin; nucleophosmin (nucleolar phosphoprotein B23, numatrin); nucleophosmin 1; nucleophosmin/nucleoplasmin family, member 1; Numatrin; testicular tissue protein Li 128

Synonyms

B23; MGC104254; NPM; NPM1; Nucleolar phosphoprotein B23; Nucleolar protein NO38; Nucleophosmin; nucleophosmin (nucleolar phosphoprotein B23, numatrin); nucleophosmin 1; nucleophosmin/nucleoplasmin family, member 1; Numatrin; testicular tissue protein Li 128

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