Phospho-STING (Ser365) (D1C4T) Rabbit Monoclonal Antibody (BSA and Azide Free)#51865,Cell Signaling Technology (CST),51865

Stimulator of interferon genes (STING, TMEM173, MITA) is a transmembrane adaptor protein that is a critical component of the cellular innate immune response to pathogenic cytoplasmic DNA (1,2). STING is a ubiquitously expressed protein found predominantly in the ER (1). The enzyme cGAMP synthase (cGAS) produces the second messenger cyclic-GMP-AMP (cGAMP) in response to cytoplasmic DNA (3,4). cGAMP binds and activates STING (3,4). In addition, detection of cytoplasmic DNA by nucleic acid sensors, including DDX41 or IFI16, results in STING activation (5,6). Following activation, STING translocates with TBK1 to perinuclear endosomes (7). The TBK1 kinase phosphorylates and activates interferon regulatory factors (IRFs) and NF-κB, which leads to the induction of type I interferon and other immune response genes (1,2,7).Following binding of cyclic dinucleotides, STING is phosphorylated by TBK1 at Ser366 (Ser365 in mouse), leading to IRF-3 activation and type I interferon upregulation (8).Ishikawa, H. and Barber, G.N. (2008)Nature455, 674-8.Zhong, B. et al. (2008)Immunity29, 538-50.Sun, L. et al. (2013)Science339, 786-91.Wu, J. et al. (2013)Science339, 826-30.Zhang, Z. et al. (2011)Nat Immunol12, 959-65.Unterholzner, L. et al. (2010)Nat Immunol11, 997-1004.Ishikawa, H. et al. (2009)Nature461, 788-92.Liu, S. et al. (2015)Science347, aaa2630.Alternate Names2610307O08Rik; Endoplasmic reticulum interferon stimulator; ERIS; Mediator of IRF3 activation; Mita; mitochondrial mediator of IRF3 activation; MMITA; Mpys; mSTING; Stimulator of interferon genes protein; stimulator of interferon protein; stimulator of interferon response cGAMP interactor 1; Sting; STING-beta; Sting1; TM173; Tmem173; Transmembrane protein 173

2610307O08Rik; Endoplasmic reticulum interferon stimulator; ERIS; Mediator of IRF3 activation; Mita; mitochondrial mediator of IRF3 activation; MMITA; Mpys; mSTING; Stimulator of interferon genes protein; stimulator of interferon protein; stimulator of interferon response cGAMP interactor 1; Sting; STING-beta; Sting1; TM173; Tmem173; Transmembrane protein 173