Phospho-Ser-Pro-Pro Motif [pSPP] Rabbit Monoclonal Antibody#14390,Cell Signaling Technology (CST),14390

The MAPK and CDK families of serine/threonine protein kinases play important roles in cell signaling and cell cycle control. These kinases phosphorylate threonine or serine followed by a proline residue (1-6). To facilitate the study and discovery of new MAPK and CDK substrates, Cell Signaling Technology has developed antibodies that bind to phospho-threonine or phospho-serine followed by proline.The S/TPP motif matches the consensus sequence for targeted phosphorylation by Cdc2 (7,8), ERK1, ERK2 (9), SAPK/JNK, CDK5, and GSK3 (10).Pearson, R.B. and Kemp, B.E. (1991)Methods Enzymol200, 62-81.Seger, R. and Krebs, E.G. (1995)FASEB J9, 726-35.Nurse, P. (2000)Cell100, 71-8.Cross, T.G. et al. (2000)Exp Cell Res256, 34-41.Yang, C.C. et al. (1998)J Protein Chem17, 329-35.Reynolds, C.H. et al. (2000)J Neurochem74, 1587-95.Shah, O.J. et al. (2003)J Biol Chem278, 16433-42.Songyang, Z. et al. (1994)Curr Biol4, 973-82.Gonzalez, F.A. et al. (1991)J Biol Chem266, 22159-63.Yang, X. and Gabuzda, D. (1998)J Biol Chem273, 29879-87.