Phospho-Stat2 (Tyr690) (D3P2P) Rabbit Monoclonal Antibody#88410,Cell Signaling Technology (CST),88410

Stat2 (113 kDa), originally purified from the nuclei of alpha-interferon-treated cells, is critical to the transcriptional responses induced by type I interferons, IFN-alpha/beta (1,2). Knockout mice with a targeted disruption of Stat2 have higher susceptibility to viral infection and altered responses to type I interferons (3). Stat2 is rapidly activated by phosphorylation at Tyr690 in response to stimulation by IFN-alpha/beta via associations with receptor-bound Jak kinases (4). Unlike other Stat proteins, Stat2 does not form homodimers. Instead, activated Stat2 forms a heterodimer with Stat1 and translocates to the nucleus. There, it associates with the DNA-binding protein p48 and forms the transcriptional activator complex, interferon-stimulated gene factor 3 (ISGF3), promoting transcription from the ISRE (5).Fu, X.Y. et al. (1992)Proc Natl Acad Sci U S A89, 7840-3.Ihle, J.N. (2001)Curr Opin Cell Biol13, 211-7.Park, C. et al. (2000)Immunity13, 795-804.Improta, T. et al. (1994)Proc Natl Acad Sci U S A91, 4776-80.Horvath, C.M. et al. (1996)Mol Cell Biol16, 6957-64.Alternate NamesIMD44; interferon alpha induced transcriptional activator; ISGF-3; MGC59816; p113; PTORCH3; Signal transducer and activator of transcription 2; signal transducer and activator of transcription 2, 113kDa; STAT113; STAT2

IMD44; interferon alpha induced transcriptional activator; ISGF-3; MGC59816; p113; PTORCH3; Signal transducer and activator of transcription 2; signal transducer and activator of transcription 2, 113kDa; STAT113; STAT2