Phospho-Stat3 (Tyr705) (D3A7) Rabbit Monoclonal Antibody (Pacific Blue^TMConjugate)#52527,Cell Signaling Technology (CST),52527

The Stat3 transcription factor is an important signaling molecule for many cytokines and growth factor receptors (1) and is required for murine fetal development (2). Research studies have shown that Stat3 is constitutively activated in a number of human tumors (3,4) and possesses oncogenic potential (5) and anti-apoptotic activities (3). Stat3 is activated by phosphorylation at Tyr705, which induces dimerization, nuclear translocation, and DNA binding (6,7). Transcriptional activation seems to be regulated by phosphorylation at Ser727 through the MAPK or mTOR pathways (8,9). Stat3 isoform expression appears to reflect biological function as the relative expression levels of Stat3α (86 kDa) and Stat3β (79 kDa) depend on cell type, ligand exposure, or cell maturation stage (10). It is notable that Stat3β lacks the serine phosphorylation site within the carboxy-terminal transcriptional activation domain (8).Heim, M.H. (2001)J Recept Signal Transduct Res19, 75-120.Takeda, K. et al. (1997)Proc Natl Acad Sci U S A94, 3801-4.Catlett-Falcone, R. et al. (1999)Immunity10, 105-15.Garcia, R. and Jove, R. (1998)J Biomed Sci5, 79-85.Bromberg, J.F. et al. (1999)Cell98, 295-303.Darnell, J.E. et al. (1994)Science264, 1415-21.Ihle, J.N. (1995)Nature377, 591-4.Wen, Z. et al. (1995)Cell82, 241-50.Yokogami, K. et al. (2000)Curr Biol10, 47-50.Biethahn, S. et al. (1999)Exp Hematol27, 885-94.Alternate NamesAcute-phase response factor; ADMIO; ADMIO1; APRF; DNA-binding protein APRF; FLJ20882; HIES; MGC16063; Signal transducer and activator of transcription 3; signal transducer and activator of transcription 3 (acute-phase response factor); STAT3

Acute-phase response factor; ADMIO; ADMIO1; APRF; DNA-binding protein APRF; FLJ20882; HIES; MGC16063; Signal transducer and activator of transcription 3; signal transducer and activator of transcription 3 (acute-phase response factor); STAT3