Phospho-Stat5 (Tyr694) (C71E5) Rabbit Monoclonal Antibody (SignalFlex^TMAlexa Fluor^®700 Conjugate)#58399,Cell Signaling Technology (CST),58399

Stat5 is activated in response to a wide variety of ligands, including IL-2, GM-CSF, growth hormone, and prolactin. Phosphorylation at Tyr694 is obligatory for Stat5 activation (1,2). This phosphorylation is mediated by Src upon erythropoietin stimulation (3). Stat5 is constitutively active in some leukemic cell types (4). Phosphorylated Stat5 is found in some endothelial cells treated with IL-3, which suggests its involvement in angiogenesis and cell motility (5). Stat5a and Stat5b are independently regulated and activated in various cell types. For instance, interferon treatment predominantly activates Stat5a in U-937 cells and Stat5b in HeLa cells (6).Gouilleux, F. et al. (1994)EMBO J13, 4361-9.Wakao, H. et al. (1994)EMBO J13, 2182-91.Okutani, Y. et al. (2001)Oncogene20, 6643-50.Demoulin, J.B. et al. (1999)J Biol Chem274, 25855-61.Dentelli, P. et al. (1999)J Immunol163, 2151-9.Meinke, A. et al. (1996)Mol Cell Biol16, 6937-44.Alternate Namesepididymis secretory sperm binding protein; GHISID2; MGF; Signal transducer and activator of transcription 5A; Signal transducer and activator of transcription 5B; STA5A; STA5B; STAT5; STAT5A; STAT5B; transcription factor STAT5B

epididymis secretory sperm binding protein; GHISID2; MGF; Signal transducer and activator of transcription 5A; Signal transducer and activator of transcription 5B; STA5A; STA5B; STAT5; STAT5A; STAT5B; transcription factor STAT5B