Phospho-TBK1/NAK (Ser172) (D52C2) Rabbit Monoclonal Antibody (Alexa Fluor^®647 Conjugate)#14590,Cell Signaling Technology (CST),14590

TBK1 (TANK-binding kinase 1)/NAK (NF-κB activating kinase) is an IκB kinase (IKK)-activating kinase and can activate IKK through direct phosphorylation (1). TBK1 was identified through association with the TRAF binding protein, TANK, and found to function upstream of NIK and IKK in the activation of NF-κB (2). TBK1 induces IκB degradation and NF-κB activity through IKKβ. TBK1 may mediate IKK and NF-κB activation in response to growth factors that stimulate PKCε activity (1). TBK1 plays a pivotal role in the activation of IRF3 in the innate immune response (3).Tojima, Y. et al. (2000)Nature404, 778-82.Pomerantz, J.L. and Baltimore, D. (1999)EMBO J18, 6694-704.Fitzgerald, K.A. et al. (2003)Nat Immunol4, 491-6.Alternate NamesFLJ11330; FTDALS4; IIAE8; NAK; NF-kappa-B-activating kinase; NF-kB-activating kinase; Serine/threonine-protein kinase TBK1; T2K; TANK binding kinase 1; TANK-binding kinase 1; TBK1

FLJ11330; FTDALS4; IIAE8; NAK; NF-kappa-B-activating kinase; NF-kB-activating kinase; Serine/threonine-protein kinase TBK1; T2K; TANK binding kinase 1; TANK-binding kinase 1; TBK1