Phospho-Tyrosine (P-Tyr-1000) MultiMab®Rabbit Monoclonal Antibody mix (HRP Conjugate)#12695,Cell Signaling Technology (CST),12695

Phospho-Tyrosine (P-Tyr-1000) MultiMab®Rabbit Monoclonal Antibody mix (HRP Conjugate) recognizes a broad range of tyrosine-phosphorylated proteins and peptides. This antibody conjugate does not cross-react with proteins or peptides containing phospho-Ser or phospho-Thr residues.

Host

Rabbit

Reactivity

All Species Expected

Application

Western Blotting: 1:1000

Platform ID

BAB642537165

Cell Signaling Technology (CST)

Headquarters

3 Trask Lane Danvers, MA 01923

Cell Signaling Technology (CST)

Contact

Tel: 877-616-2355,978-867-2388
Fax: 877-616-2355

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NamePhospho-Tyrosine (P-Tyr-1000) MultiMab®Rabbit Monoclonal Antibody mix (HRP Conjugate)#12695
Cat. No.12695
HostRabbit
SensitivityEndogenous
ReactivityAll Species Expected
ApplicationWestern Blotting: 1:1000
ImmunogenIgG
FormulationSupplied in 140 mM NaCl, 3 mM KCI, 10 mM sodium phosphate (pH 7.4) dibasic, 2 mM potassium phosphate monobasic, 2 mg/mL BSA, and 50% glycerol. Store at –20°C.Do not aliquot the antibody.
StorageSupplied in 140 mM NaCl, 3 mM KCI, 10 mM sodium phosphate (pH 7.4) dibasic, 2 mM potassium phosphate monobasic, 2 mg/mL BSA, and 50% glycerol. Store at –20°C.Do not aliquot the antibody.
Regulatory StatusResearch Use Only

Scientific Background

Tyrosine phosphorylation plays a key role in cellular signaling (1). Research studies have shown that in cancer, unregulated tyrosine kinase activity can drive malignancy and tumor formation by generating inappropriate proliferation and survival signals (2). Antibodies specific for phospho-tyrosine (3,4) have been invaluable reagents in these studies. The phospho-tyrosine monoclonal antibodies developed by Cell Signaling Technology are exceptionally sensitive tools for studying tyrosine phosphorylation and monitoring tyrosine kinase activity in high throughput drug discovery.Schlessinger, J. (2000)Cell103, 211-25.Blume-Jensen, P. and Hunter, T. (2001)Nature411, 355-65.Ward, S.G. et al. (1992)J Biol Chem267, 23862-9.Glenney, J.R. et al. (1988)J Immunol Methods109, 277-85.

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