Purifed anti-SHC1 Antibody, SHC1, O91H8,BioLegend,669702

Host

Mouse

Reactivity

Human, Mouse

Application

WB -Quality testedIP, KO/KD-WB -VerifiedICC, IHC-P -Reported in the literature, not verified in house

Platform ID

BAB761636292

BioLegend

Headquarters

8999 BioLegend Way San Diego, CA 92121 United States

BioLegend

Contact

Tel: 1-858-455-9588
Fax: +49 (4131) 7023913

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Product Specifications
Scientific Background

Specifications

NamePurifed anti-SHC1 Antibody, SHC1, O91H8
Cat. No.669702
HostMouse
RRIDAB_2814514 (BioLegend Cat. No. 669701)AB_2814515 (BioLegend Cat. No. 669702)
IsotypeMouse IgG1, κ
ReactivityHuman, Mouse
ApplicationWB -Quality testedIP, KO/KD-WB -VerifiedICC, IHC-P -Reported in the literature, not verified in house
ClonalityMonoclonal
Clone NumberO91H8
Concentration0.5 mg/ml
TargetSHC1
ImmunogenFull length recombinant human SHC1 protein
PurityThe antibody was purified by affinity chromatography.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.
Regulatory StatusResearch Use Only

Scientific Background

SHC1 is a ubiquitously expressed adaptor protein involved in receptor tyrosine kinase signaling including the activation of the RAS/Raf/MAPK pathway. Three isoforms of SHC1 (p66, p52, p46) have been described, each with unique cellular functions. SHC1 has an SH2 domain and a protein tyrosine phosphate binding (PTB) domain, which recognize activated receptor tyrosine kinases. Tyrosine residues located in the CH1 domain of SHC1 are phosphorylated by tyrosine kinases and serve as docking sites for proteins such as Grb2. SHC1-bound Grb2 recruits SOS, which activates Ras, thereby promoting cell proliferation and differentiation.

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