Purified Purified anti-Estrogen Receptor alpha Antibody, Estrogen Receptor alpha, W23263D,BioLegend,648842

Estrogen receptor alpha is a nuclear hormone receptor that functions as a transcription factor activated by the hormone estrogen. Upon binding estrogen, ESR1 translocates to the nucleus where it binds to estrogen response elements in the DNA to regulate gene expression. It plays a crucial role in the development and maintenance of reproductive tissues, as well as in bone density, cardiovascular function, and behavior. ESR1 is also a key player in the pathogenesis of hormone-sensitive cancers such as breast, cervical and uterine cancer, where it influences tumor growth and progression.