Purified anti-A2M Antibody, A2M, A21084F,BioLegend,649851
This antibody (clone A21084F) does not cross-react with mouse A2M in Western Blot.For use in immunohistochemistry on formalin-fixed paraffin-embedded tissue (IHC-P), it is recommended to perform antigen retrieval using either Citrate Buffer, 10X (Cat. No. 420902) or Tris-EDTA pH 9.0 Antigen Retrieval Buffer (10X) (Cat. No. 422704).This product is not recommended for use in immunocytochemistry (ICC).For use in intracellular flow cytometry (ICFC), fixation with fixation buffer (Cat. No. 420801) and permeabilization with True-PhosTM Perm Buffer (Cat. No. 425401) is recommended.
Host
Rat
Reactivity
Human
Application
WB - Quality testedIHC-P, ICFC - Verified
Platform ID
BAB615872499
BioLegend
Contact
Tel: 1-858-455-9588
Fax: +49 (4131) 7023913
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Specifications
Scientific Background
Alpha-2-macroglobulin (A2M) is a large plasma protein that plays a crucial role in the immune system and homeostasis. Secreted primarily by the liver, A2M mainly functions as a broad-spectrum protease inhibitor, capable of trapping and neutralizing a wide variety of proteases. This action is protective against excessive tissue damage during inflammation and other immune responses. A2M also has roles in binding and clearing various cytokines, growth factors, and other bioactive molecules from the bloodstream, thereby regulating their activity. Finally, A2M is also involved in the clearance of protein fragments and other cellular debris, contributing to overall tissue repair and maintenance. Due to its role in protein clearance and inflammation modulation, A2M may also play a role in the progression of Alzheimer’s disease.
Category Paths
- Products>Primary Antibodies>IHC Antibodies
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