Purified anti-ATG7 Antibody, ATG7, A17129A,BioLegend,625851

ATG7 is an E1-like ligase that plays a central role in autophagosome biogenesis by conjugating ATG5 to ATG12 which degrades and recycles damaged organelles, protein aggregates, and invading pathogens. ATG7 interacts with other ATG proteins, such as ATG3, ATG10, and ATG16L1, to form a complex that is required for autophagy, also regulates immunity, cell death, and protein secretion, and independently regulates the cell cycle and apoptosis. It also participates in lipidation of the ATG8 protein, which is essential for autophagosome formation. Additionally, ATG7 has been shown to interact with other proteins outside of the autophagy pathway, such as p53, to regulate apoptosis. Disrupting ATG7-dependent autophagy has been shown to cause electromotility disturbances, outer hair cell loss, and deafness in mice. ATG7 dysfunction has been associated with various human diseases, including cancer, neurodegeneration, and infection. ATG7 dysfunction and disease was found in patients with biallelic ATG7 variants and childhood-onset neuropathology. Furthermore, ATG7 has been shown to induce basal autophagy and rescue autophagic deficiency in CryABR120Gcardiomyocytes.