Purified anti-ApoER2 (LRP8) Antibody, ApoER2, 25G5,BioLegend,862101
Host
Rat
Reactivity
Human, Mouse, Rat
Application
WB -Quality tested
Platform ID
BAB861122309
BioLegend
Contact
Tel: 1-858-455-9588
Fax: +49 (4131) 7023913
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Product Specifications
Scientific Background
Specifications
NamePurified anti-ApoER2 (LRP8) Antibody, ApoER2, 25G5
Cat. No.862101
HostRat
RRIDAB_2801239 (BioLegend Cat. No. 862101)AB_2801240 (BioLegend Cat. No. 862102)
IsotypeRat IgG2a, κ
ReactivityHuman, Mouse, Rat
ApplicationWB -Quality tested
ClonalityMonoclonal
Clone Number25G5
Concentration0.5 mg/ml
TargetApoER2
PurityThe antibody was purified by affinity chromatography.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.
Regulatory StatusResearch Use Only
Scientific Background
LDL Receptor Related Protein 8 (LRP8), also known as ApoER2, is a receptor for members of low-density lipoproteins. LRP8 interacts with its ligand reelin, and triggers reelin signaling to regulate cellular processes such as neuronal cell migration and long-term potentiation of mature neurons. LRP8 also interacts with and downregulates APP endocytosis. This interactions leads to increased amyloid beta production, demonstrating a major role for LRP8 in the pathogenesis of Alzheimer’s disease.
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