Purified anti-Aurora A Antibody, Aurora A, W23093D,BioLegend,687452

Aurora A (AURKA) is a serine/threonine kinase and a crucial regulator of mitosis. It is a member of the Aurora kinase family, which plays key roles in cell cycle regulation, spindle formation, and chromosome segregation. AURKA is highly conserved among eukaryotic organisms and is essential for maintaining genomic stability. Aurora A is predominantly active during the G2/M phase of the cell cycle which promotes the recruitment of pericentriolar material (PCM) to centrosomes, facilitating their maturation. Aurora A phosphorylates and activates several substrates involved in mitotic entry, such as PLK1 (Polo-like kinase 1) and CDC25B which enable the activation of cyclin-dependent kinases, driving the cell into mitosis. Aurora A stabilizes spindle microtubules by interacting with proteins such as TPX2 (Targeting Protein for Xklp2) and ensures proper bipolar spindle formation facilitating a prerequisite for accurate chromosome alignment and segregation. Aberrant expression or dysregulation of AURKA is implicated in oncogenesis. Overexpression is frequently observed in various cancers, including breast, ovarian, and colorectal cancers.