Purified anti-BLK Antibody, BLK, W21005C,BioLegend,642351
This product (clone W21005C) may cross-react with other members of the Src kinase family.This product (clone W21005C) is not recommended for use in immunocytochemistry (ICC) or immunohistochemistry (IHC).For use in intracellular flow cytometry (ICFC), permeabilization with True-PhosTM Perm Buffer (Cat. No. 425401) is recommended. Fixation/permeabilization with Cyto-FastTM Fix/Perm Buffer Set (Cat. No. 426803) is not recommended.This antibody does not cross react with mouse BLK in Western Blot (WB).
Host
Rat
Reactivity
Human
Application
WB - Quality testedICFC - Verified
Platform ID
BAB648156995
BioLegend
Contact
Tel: 1-858-455-9588
Fax: +49 (4131) 7023913
Email:
Specifications
Scientific Background
BLK is a non-receptor tyrosine kinase primarily expressed in B lymphocytes and other cells of the B-cell lineage. BLK belongs to the Src family of kinases and plays a critical role in B cell receptor signaling, which is essential for the activation, differentiation, and proliferation of B cells. Phosphorylation of target proteins by BLK helps transmit signals that guide B cell development and activation. Dysregulation of BLK has been associated with various immune disorders, including autoimmune diseases and certain types of B cell malignancies. Outside of B cells, BLK is also expressed in a variety of immune and non-immune cells including plasmacytoid dendritic cells, pancreatic β cells, and bone marrow progenitor cells.
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