Purified anti-Beclin-1 Antibody anti-Beclin-1 - O93F3,BioLegend,849701
Host
Mouse
Reactivity
Human, Rat, Mouse
Application
WB -Quality tested
Platform ID
BAB574292467
BioLegend
Contact
Tel: 1-858-455-9588
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Product Specifications
Scientific Background
Specifications
NamePurified anti-Beclin-1 Antibody anti-Beclin-1 - O93F3
Cat. No.849701
HostMouse
RRIDAB_2687306 (BioLegend Cat. No. 849701)AB_2687307 (BioLegend Cat. No. 849702)
IsotypeMouse IgG1, κ
ReactivityHuman, Rat, Mouse
ApplicationWB -Quality tested
ClonalityMonoclonal
Clone NumberO93F3
Concentration0.5 mg/mL
TargetBeclin-1
ImmunogenFull length recombinant human Beclin-1 protein (NP_003757) produced in HEK293T cells
PurityThe antibody was purified by affinity chromatography.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.
Regulatory StatusResearch Use Only
Scientific Background
Beclin-1 plays a central role in autophagy and is involved in autophagosome formation. It acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate. Beclin-1 is necessary for the initiation of autophagy, and it has been shown to be reduced in the brains of patients with Alzheimer’s disease. Reduced Beclin-1 levels lead to decreased autophagy, the accumulation of Aβ peptides, and neurodegeneration in mouse models of Alzheimer's disease.
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