Purified anti-CD102 (ICAM-2) Antibody, CD102, W22039C,BioLegend,631351

For western blotting (WB) it is recommended to heat the cell lysate at 37 °C for 30 min rather than boiling it.For immunocytochemistry (ICC), either Fixation Buffer (Cat. No. 420801) or 4% paraformaldehyde followed by methanol permeabilization is recommended.The reactivity of this antibody (clone W22039C) in cell surface flow cytometry is able to be blocked by another BioLegend antibody (clone CBR-IC2/2) (Cat. No. 328502).

Host

Mouse

Reactivity

Human

Application

FC - Quality testedICC, WB - Verified

Platform ID

BAB399131527

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Contact

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Product Specifications
Scientific Background

Specifications

NamePurified anti-CD102 (ICAM-2) Antibody, CD102, W22039C
Cat. No.631351
HostMouse
RRIDAB_3097547 (BioLegend Cat. No. 631351)AB_3097547 (BioLegend Cat. No. 631352)
IsotypeMouse IgG2b, κ
ReactivityHuman
ApplicationFC - Quality testedICC, WB - Verified
ClonalityMonoclonal
Clone NumberW22039C
Concentration0.5 mg/mL
TargetCD102
ImmunogenHuman CD102 (ICAM-2) recombinant protein fragment
PurityThe antibody was purified by affinity chromatography.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.
Regulatory StatusResearch Use Only

Scientific Background

CD102 (ICAM-2) is a 55 kD type I transmembrane glycoprotein which belongs to the immunoglobulin superfamily. It is also known as Intercellular Adhesion Molecule-2, or ICAM-2. CD102 is constitutively expressed on vascular endothelial cells, some lymphocytes, monocytes, and platelets. CD102 is thought to be involved in lymphocyte recirculation, and in co-stimulation of the immune response. CD102 and CD54 in endothelial cells, such as in blood-brain barrier, are essential for assisting T cell polarization and crawling and diapedesis. CD102 is a counter receptor of LFA-1 (CD11a/CD18), DC-SIGN and MAC-1.

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