Purified anti-CD117 (c-kit) Phospho (Tyr703) Antibody, CD117, A22001B,BioLegend,619551

Proto-oncogene CD117/c-KIT is a type III receptor tyrosine kinase that binds Stem Cell Factor (SCF). CD117 is used to identify certain types of hematopoietic progenitors in bone marrow, such as hematopoietic stem cells (HSC), multipotent progenitors (MPP), and common myeloid progenitors (CMP). Expression of CD117/c-KIT is also found in stem cell precursors from prostate, liver, and heart. CD117/c-KIT signaling plays a role in cell survival, proliferation, and differentiation; hence, its activation is required for melanocyte survival, hematopoiesis and gametogenesis. Aberrant activation of CD117/c-KIT due to gene mutations has been associated with gastrointestinal stromal tumors, testicular seminoma, mast cell disease, melanoma, acute myeloid leukemia, and others, while loss of activation is associated with piebaldism.