Purified anti-CD14 Antibody, CD14, W23074F,BioLegend,651951

For use of this antibody (clone W23074F) in immunohistochemistry with formalin-fixed, paraffin-embedded tissues (IHC-P), we recommend antigen retrieval with either Sodium Citrate (Cat. No. 928502), or Tris-EDTA (10 mM Tris, 1 mM EDTA, 0.05% Tween-20, pH 9.0).This antibody (clone W23074F) is not suitable for western blot, flow cytometry or immunocytochemistry.

Host

Rat

Reactivity

Human

Application

IHC-P - Quality tested

Platform ID

BAB649856179

BioLegend

Headquarters

8999 BioLegend Way San Diego, CA 92121 United States

BioLegend

Contact

Tel: 1-858-455-9588
Fax: +49 (4131) 7023913

Email:

Product Specifications
Scientific Background

Specifications

NamePurified anti-CD14 Antibody, CD14, W23074F
Cat. No.651951
HostRat
RRIDAB_3662331 (BioLegend Cat. No. 651951)AB_3662331 (BioLegend Cat. No. 651952)
IsotypeRat IgG2b, κ
ReactivityHuman
ApplicationIHC-P - Quality tested
ClonalityMonoclonal
Clone NumberW23074F
Concentration0.5 mg/mL
TargetCD14
ImmunogenRecombinant peptide containing the full-length extracellular domain of human CD14
PurityThe antibody was purified by affinity chromatography.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.
Regulatory StatusResearch Use Only

Scientific Background

CD14 is a glycosylphosphatidylinositol (GPI)-linked membrane glycoprotein also known as LPS receptor. CD14 is expressed at high levels on monocytes and macrophages, and at lower levels on granulocytes. Some dendritic cell populations such as interfollicular dendritic cells, reticular dendritic cells, and Langerhans cells have also been reported to express CD14. It plays an important role in the innate immune system, and is the first pattern recognition receptor identified. CD14 primarily binds to bacterial lipopolysaccharide (LPS), a component of the outer membrane of Gram-negative bacteria. By binding to LPS, CD14 initiates a signaling cascade that leads to the clearance of pathogens.

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