Purified anti-CD29 Integrin beta1 Antibody anti-CD29 - P5D2,BioLegend,921304

Clone P5D2 interferes with binding of integrin-bearing cells to fibronectin, laminin and collagen but not vitronectin coated surfaces.P5D2 reacts with the integrin β1 subunit and inhibits the function of all β1 integrins.

Host

Mouse

Reactivity

Human

Application

FC - Quality testedBlock - Reported in the literature, not verified in house

Platform ID

BAB327465943

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Product Specifications
Scientific Background

Specifications

NamePurified anti-CD29 Integrin beta1 Antibody anti-CD29 - P5D2
Cat. No.921304
HostMouse
RRIDAB_2650837 (BioLegend Cat. No. 921303)AB_2650620 (BioLegend Cat. No. 921304)
IsotypeMouse IgG1, κ
ReactivityHuman
ApplicationFC - Quality testedBlock - Reported in the literature, not verified in house
ClonalityMonoclonal
Clone NumberP5D2
Concentration0.5 mg/ml
TargetCD29
ImmunogenThe P5D2 monoclonal antibody was generated against human fibroblast cells (HT1080).
PurityThe antibody was purified by affinity chromatography.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.
Regulatory StatusResearch Use Only

Scientific Background

CD29 is a 130 kD single chain type I glycoprotein also known as integrin β1, VLA-β chain, or gpIIa. It is broadly expressed on a majority of hematopoietic and non-hematopoietic cells, including leukocytes (although at low level on granulocytes), platelets, fibroblasts, endothelial cells, epithelial cells, and mast cells. CD29 is a member of the integrin family. It is non-covalently associated with integrin α1-α6 chains to form VLA-1 to VLA-6 molecules, respectively. Integrins, which include CD29, bind to several cell surface (e.g. VCAM-1, MadCAM-1) and extracellular matrix molecules. CD29 acts as a fibronectin receptor and is involved in a variety of cell-cell and cell-matrix interactions.

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