Purified anti-CD38, CD38, W22190F,BioLegend,632351

CD38 is a widely-expressed, multifunctional protein whose role is best studied in the immune system, where it is expressed at varying levels in multiple immune cell types including lymphocytes, monocytes/macrophages, dendritic cells and NK cells. CD38 functions in cell signaling via protein-protein interactions with cell membrane proteins in other immune cell types. For example, CD38 interacts with the T cell receptor complex in T cells and the B cell co-receptor complex in B cells. CD38 also binds to CD31/PECAM in blood vessels to mediate lymphocyte adhesion. Additionally, CD38 has intrinsic enzymatic activity, catalyzing the synthesis of ADP ribose, cyclic ADP ribose, or nicotinamide from NAD. Due to the influence the synthesized molecules have on calcium dynamics, CD38 plays a role in diverse physiological processes, including regulating insulin secretion and modulation of neurotransmitter release.