Purified anti-COMT Antibody, COMT, A17180E,BioLegend,604551

Catechol-O-methyltransferase (COMT) catalyzes the addition of methyl groups to catecholamine hormones and neurotransmitters; in particular: dopamine, norepinephrine, and epinephrine. Norepinephrine and epinephrine are key mediators of the sympathetic nervous system, while dopamine is an important neurotransmitter in the regulation of mood and behavior. Since O-methylation inactivates target catecholamines and leads to its degradation, COMT activity has significant implications for human health. The Val158Met polymorphism of the COMT gene is associated with mental disorders such as schizophrenia, obsessive compulsive disorder, bipolar disorder, and substance dependence.