Purified anti-CRMP5 Antibody, CRMP5, A18231D,BioLegend,614551

CRMP5 (Collapsin Response Mediator Protein 5 or DPYSL5) is a member of the CRMP family and is involved in regulation of the cytoskeleton. CRMP5 acts as a negative regulator of microtubule stability and dynamics and participates in the fibroblast growth factor (FGF) signaling pathway, regulating axon guidance and neuronal development. CRMP5 has been implicated in several human diseases. In cancer cells, CRMP5 regulates cancer cell migration, invasion, and proliferation through its interaction with the tumor suppressor protein, PTEN. Mutations in CRMP5 are related to neurodevelopmental disorders, including X-linked intellectual disability and autism spectrum disorder. CRMP5 regulates tau protein degradation through its interaction with microtubules and enzymes, suggesting its role in neuroinflammation and Alzheimer's disease.