Purified anti-CTCF Antibody, CTCF, W19193A,BioLegend,942502

CTCF is an 83 kD transcription factor found in the nucleoplasm, which translocates to the nucleolus when the cell is undergoing cell differentiation. This protein can act as an insulator protein by binding to an unmethylated imprinting control region (ICR) structure and prevent the activation of cis-acting elements which in turn prevents gene activation. CTCF becomes further involved in gene regulation when it forms a complex with cohesin. This complex can stabilize the formation of a chromatin loop, which can promote or repress the binding of other transcription factors to the promoter and enhancer, leading to gene activation or gene repression respectively. CTCF has a role as a tumor suppressor, when the gene goes through a mutation or deletion there is a rise in variance in CpG methylation throughout the genome. This methylation contributes to the development of aggressive and invasive tumors which are seen in breast, endometrial and bladder cancers.