Purified anti-Cbl Antibody anti-Cbl - Poly6330,BioLegend,633001
This polyclonal was generated using an immunogen that corresponds to the C-terminus of c-Cbl. Due to poor sequence homology between the C-termini of c-Cbl and other Cbl family members, we do not predict this antibody will cross-react with other Cbl proteins.At concentrations greater than a 1:1000 dilution, this antibody may produce minor non-specific bands in certain lysates.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Application
WB -Quality tested
Platform ID
BAB028342005
BioLegend
Contact
Tel: 1-858-455-9588
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Product Specifications
Scientific Background
Specifications
NamePurified anti-Cbl Antibody anti-Cbl - Poly6330
Cat. No.633001
HostRabbit
RRIDAB_2070439 (BioLegend Cat. No. 633001)
IsotypeRabbit Polyclonal IgG
ReactivityHuman, Mouse, Rat
ApplicationWB -Quality tested
ClonalityPolyclonal
Clone NumberPoly6330
ConcentrationLot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.)
TargetCbl
Immunogenpeptide mapping to the carboxy terminal domain of human Cbl
PurityThe antibody was purified by affinity chromatography.
FormulationThis antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% gelatin.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.Do not freeze.
Regulatory StatusResearch Use Only
Scientific Background
The proto-oncogene c-Cbl was initially identified as the cellular homologue of v-Cbl oncogene that induces pre-B cell lymphomas and myeloid leukemias in mice. The Cbl family comprises three mammalian proteins, c-Cbl, Cbl-b, and Cbl-3; among these, c-Cbl and Cbl-b are expressed in hemopoietic cells, whereas Cbl-3 is expressed only in epithelial tissues. Cbl proteins can function as E3 ubiquitin (Ub) ligases, and in more recent studies Cbl has been implicated in the negative regulation of various RTKs.
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