Purified anti-Centrin 2 Caltractin Antibody anti-Centrin 2 - W16110A,BioLegend,698601

Centrin, also known as caltractin, was first identified in the green algaTetraselmis striataand is a member of the highly conserved EF-hand superfamily. Centrins are small calcium binding proteins and play essential roles in the duplication and segregation of microtubule organizing centers (MTOCs). All of the three identified human centrins contain four EF-hand motifs and share high amino acid sequence homology. Human Centrin-1 expression is restricted to male germ cells and retina, while Centrin-2 and Centrin-3 are ubiquitously expressed. In addition to its function in centrosome duplication, Centrin-2 has been found to be present in both cytosol and nucleus. Centrin-2 forms a trimeric complex with the human homolog of Rad23B and the xeroderma pigmentosum group C (XPC) protein. The Centrin-2/Rad23B/XPC complex acts as an essential component of the nucleotide excision repair (NER) pathway.