Purified anti-Cofilin 1 Antibody, Cofilin 1, A18040J,BioLegend,865301

For WB on brain lysates, 5 - 10 µg/mL is recommended.

Host

Mouse

Reactivity

Human, Mouse, Rat

Application

WB -Quality testedIHC-P, ICC -Verified

Platform ID

BAB613473651

BioLegend

Headquarters

8999 BioLegend Way San Diego, CA 92121 United States

BioLegend

Contact

Tel: 1-858-455-9588
Fax: +49 (4131) 7023913

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Product Specifications
Scientific Background

Specifications

NamePurified anti-Cofilin 1 Antibody, Cofilin 1, A18040J
Cat. No.865301
HostMouse
RRIDAB_2810771 (BioLegend Cat. No. 865301)AB_2810772 (BioLegend Cat. No. 865302)
IsotypeMouse IgG1, κ
ReactivityHuman, Mouse, Rat
ApplicationWB -Quality testedIHC-P, ICC -Verified
ClonalityMonoclonal
Clone NumberA18040J
Concentration0.5 mg/mL
TargetCofilin 1
ImmunogenHuman CFL1 recombinant protein (a.a. Met 1 - Leu 166)
PurityThe antibody was purified by affinity chromatography.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.
Regulatory StatusResearch Use Only

Scientific Background

Cofilin 1 is a ubiquitously expressed actin-regulating protein that binds to and depolymerizes filamentous actin (F-actin), as well as inhibits G-actin polymerization in a pH-dependent mechanism. Cofilin 1 plays a major role in cell migration, particularly tumor cell migration and invasion. A recent study using colorectal cancer as model, compared expression of cofilin 1 in cancer tissue and adjacent non-tumor tissue and suggested that it may be used as a novel diagnostic tumor marker in various cancers4.

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