Purified anti-DNMT3B Antibody anti-DNMT3B - W15184A,BioLegend,695202

DNA (cytosine-5-)-methyltransferase 3 beta, also known as DNMT3B, is an enzyme responsible for establishing DNA methylation patterns. DNA methyltransferases in mammals are comprised of four family members: DNMT1, DNMT3A, DNMT3B, and DNMT3L. DNMT3B, as well as DNMT3A, act as de novo methyltransferases that modify unmethylated DNA, whereas DNMT1 functions in the maintenance of DNA methylation pattern. DNA methylation is a covalent modification that involves the transfer of a methyl group from S-adenosylmethionine to the 5’ cytosine residue at CpG dinucleotides of the genomic DNA. CpG methylation is usually associated with transcriptional repression and is required for embryonic development, imprinting, genomic stability, and X-chromosome inactivation. Defects in DNMT3B gene in human cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome.