Purified anti-E2F1 Antibody , E2F1, KH20,BioLegend,606051

E2F1 is a member of the E2F family of transcription factors, which is comprised of 6 members that display both activator and repressor functions. The primary functions of E2F1 are transcription activation and cell cycle regulation, namely in replication, DNA-damage response and repair, and apoptosis. E2F1 activation during G1 phase of cell cycle is vital for the transition into S phase and the subsequent replication and synthesis of DNA. Beyond its role in cell cycle control, E2F1 is a regulator of metabolism, primarily through β cell proliferation, insulin secretion, endocrine function, and adipogenesis. E2F1 activity is regulated through its binding to phosphorylated retinoblastoma protein (pRB) and through acetylation when in its pRB-free form.E2F1 represents a critical target in cancer therapy. Through its stimulation of mTORC1 activity and tumor malignancy and growth, as well as its contribution to the Warburg effect by inducing glycolytic genes, E2F1 often behaves as an oncogene. Additionally, E2F1 can function as a tumor suppressor. Tumor-suppressive properties stem from its role in apoptosis through association with p53 and p73, as well as through inhibition of the NF-κB signaling pathway.