Purified anti-FAF1 Antibody, FAF1, CPTC-FAF1-1,BioLegend,870601

FAS-associated factor 1 (FAF1) is an evolutionarily conserved protein with multiple protein interaction domains, including a FAS-interacting domain (FID), a death effector domain interacting domain (DEDID), and multi-ubiquitin-related domains. Initially identified as a member of FAS death-inducing signaling complex, FAF1 plays diverse roles in apoptotic and survival pathways. It may also serve as a scaffolding protein that regulates protein degradation in the ubiquitin-proteasome pathway. FAF1 is abundantly expressed in the brain where it modulates cell death. FAF1 also serves as a substrate for parkin, a key protein implicated in the pathogenesis of Parkinson’s disease (PD). Wild type parkin ubiquitinates FAF1 and promotes its degradation, while PD-linked mutant parkin causes abnormal accumulation of FAF1.