Purified anti-FAP, FAP, A21107A,BioLegend,621152

Fibroblast activation protein (FAP) is a cell surface and soluble protein with diverse functions in tissue homeostasis and diseases. As a prolyl peptidase, FAP cleaves peptide bonds following a proline residue. Primarily expressed by activated fibroblasts, FAP plays a crucial role in tissue remodeling and repair. Capable of being shed into the cellular milieu, FAP is involved in the breakdown and modification of the extracellular matrix, which is essential for tissue regeneration during wound healing and tissue repair. Moreover, FAP has been found to be overexpressed in the tumor microenvironment, where it potentially promotes tumor growth, invasion, and metastasis. This association with cancer has led to investigations exploring FAP as a potential therapeutic target for cancer treatment. FAP is inactive when monomeric and must form a homodimer to become functional for both the cell surface and soluble forms.