Purified anti-GM130, W18248A Antibody,BioLegend,937001
This clone does not recognize mouse GM130 by western blot.This clone was tested for ICC using HeLa cells fixed with 4% PFA and permeabilized with Triton X-100 or methanol. Both methods were compatible with GM130 staining.
Host
Rat
Reactivity
Human
Application
WB - Quality testedICC, IP - Verified
Platform ID
BAB019546229
BioLegend
Contact
Tel: 1-858-455-9588
Fax: +49 (4131) 7023913
Email:
Specifications
Scientific Background
GM130 is a structural cis-Golgi protein that plays an essential role in vesicular transport. Mitotic fragmentation of the Golgi apparatus occurs through the CDK1-dependent regulation of the physical interaction between GM130 and the vesicle docking protein p115. Biochemical or genetic disruption of GM130 results in defective Golgi assembly. GM130 also plays a role in activating TPX2, a spindle assembly factor, to produce microtubule nuclei surrounding the Golgi, which are then directly bound by GM130 during mitotic events. Aberrant GM130 expression has been described in multiple malignancies where cells show altered Golgi structure and loss of polarity, lending to increased migration and invasion.
Category Paths
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