Purified anti-GSK3β Phospho (Ser9) Antibody, GSK3b Phospho (Ser9), A21018C,BioLegend,618551

Glycogen synthase kinase 3 beta or GSK3β, is a 420 aa length constitutively active serine-threonine kinase that phosphorylates more than 100 target proteins. GSK3β is involved in several biological activities including glycogen metabolism, cell signaling, cellular transport, cell proliferation, apoptosis, and others. The activity of GSK3β is regulated by phosphorylation at different residues. Phosphorylation at tyrosine 216 enhances GSK3β kinase activity, while phosphorylation at serine 9 decreases kinase activity. In addition, GSK3β activity can also be regulated by cellular localization and/or formation of protein complexes. GSK3β has been associated with several diseases including type 2 diabetes, Alzheimer’s disease, inflammation, cancer, addiction, and bipolar disorders.