Purified anti-HCN1 Antibody, HCN1, N70/28,BioLegend,601051

Hyperpolarization-activated cyclic nucleotide-gated (HCN) 1 channel is a member in the superfamily of six-transmembrane segment channels, and related to cyclic nucleotide-gated channels and voltage-dependent K+ channels. Four isoforms, HCN1-4, have been identified with up to 60% of sequence homology. The transmembrane α-helices and C-terminal cyclic-nucleotide binding domain of HCN channels are important for K+ ions selectivity filter and cAMP modulation. HCN1 is widely expressed in the nervous system where it plays a role in regulating membrane potential, dendritic integration, neuronal pacemaking, and action potential threshold.